Transcriptome profiling of different types of human respiratory tract cells infected by SARS-CoV-2 highlight an unique role for inflammatory and interferon response

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) at the end 2019 has caused a large global outbreak and now become major public health issue. However, there is currently lack data underlying how human host interacts with SARS-CoV-2 virus. In current study, We performed Venn-analysis, Gene ontology (GO), KEGG pathway analysis Protein-protein interaction whole transcriptome studies aim clarifying genes pathways potentially altered during tract cell infection SARS-CoV-2. found 36 overlapping upregulated among different types cells after viral infection. Further functional enrichment revealed these Differential Expressed Genes (DEGs) are most likely involved in biological processes related to inflammatory response cytokine, component extracellular space I-kappa B/NF-kappa B complex, molecular function protein binding cytokine activity. highlighted conical casual TNF, NF-kappa B, Cytokine-cytokine receptor IL-17 signaling SARS CoV-2 CXCL1, CXCL2, CXCL3, CXCL8, CXCL10, IL32, CX3CL1, CCL20, IRF1, NFKB2 NFKB1A up-regulated which may explain storms associated cases COVID-19.